Folklore vs TendiPet: Which Is Better in 2026?

Folklore by Helena Bioinformatics is a free public web tool for automated ACMG/AMP classification of individual human germline variants on GRCh38. Enter a supported HGVS expression, SPDI, rsID or genomic coordinate for a nuclear SNV or simple insertion or deletion smaller than 50 bp. When the variant resolves uniquely and interpretation succeeds, Folklore shows the normalized variant, the automated classification and reported criteria, and available evidence such as ClinVar assertions and population allele frequencies, with source versions. ClinVar assertions are displayed separately from the automated classification. No account is required for public single-variant queries. Clinical use of a result requires review by a qualified genetics professional.

The public service is available at https://folklore.helena.bio/. Its browser interface lets a visitor start with one variant identifier and inspect the returned interpretation and supporting annotations. This makes the service relevant to researchers, genetics professionals and learners looking for an accessible way to explore ACMG/AMP variant classification and the evidence reported for a supported variant. The public workflow concerns a single variant on the GRCh38 reference assembly.

The distinction between automated classification and existing database assertions matters when reading a result. Folklore presents ClinVar assertions separately, so visitors can examine those records alongside the automated interpretation rather than treating them as the same conclusion. Available source versions and supporting evidence help readers understand the information behind a result. Evidence availability and successful interpretation depend on the submitted variant; a uniquely resolved input and a successful query are necessary before an interpretation can be shown.

Visitors can read the public guide at https://folklore.helena.bio/acmg-variant-classification and a worked example at https://folklore.helena.bio/examples/acmg-variant-classification before submitting their own supported query. These pages explain the public single-variant workflow and provide a concrete example of the information to review. The public browser service is free to access without registration. Its automated output should be reviewed in the relevant clinical and scientific context by a qualified genetics professional before clinical use.

Tendi (tendipet.com) helps caregivers of dogs with IVDD (intervertebral disc disease) find calm, plain-language next steps. Free educational guides cover emergency signs, diagnosis, medical and surgical care, and recovery — with a specialty-veterinary source trail.

The IVDD Path is organized around real caregiver questions: what to watch for in the urgent first hours, how to think through care choices with your veterinarian, how to manage crate rest, what rehab and long-term mobility can look like, and where to find trustworthy specialty sources.

Tendi is built for dog owners and caregivers who feel overwhelmed after a sudden back or neck problem and want clear, compassionate guidance. There are no miracle claims and no diagnose/cure promises — education supports, never replaces, your veterinarian. Start where you are.

What problem it solves

When a dog shows signs of IVDD, caregivers are often scared and flooded with conflicting information. Tendi offers calm, plain-language educational guides so they can understand the path ahead and have better conversations with their veterinarian.